Rabdosia rubescens (Hemsl.)
Rabdosia rubescens (Hemsl.)
CAS: 28957-04-2
Molecular Formula: C20H28O6
Rabdosia rubescens (Hemsl.) - Names and Identifiers
Rabdosia rubescens (Hemsl.) - Physico-chemical Properties
| Molecular Formula | C20H28O6 |
| Molar Mass | 364.44 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | 248-250°C |
| Boling Point | 599.8±50.0 °C(Predicted) |
| Solubility | DMSO: >20mg/mL |
| Appearance | Powder |
| Color | White or off-white |
| pKa | 10.96±0.70(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| Physical and Chemical Properties | It is derived from the whole grass of the genus Fructus Lamiaceae (Rabdosia rubescens). |
| In vitro study | Oridonin effectively inhibits the proliferation of various cancer cells, including cells from prostate cancer (LNCaP, DU145, PC3), breast cancer (MCF-7, MDA-MB231), non-small cell lung cancer (NSCL) (NCI-H520, NCI-H460, NCI-H1299), acute promyelocytic leukemia (NB4), as well as Glioblastoma (U118, U138) cell proliferation, ED50s range from 1.8 to 7.5 μg/ml. The antitumor activity of Oridonin may be due to its inhibitory effect on NF-κB and MAPKs signaling pathways. |
| In vivo study | LD50: Mice 35-40 mg/kg. |
Rabdosia rubescens (Hemsl.) - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 40 - Limited evidence of a carcinogenic effect |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | NZ8177000 |
| HS Code | 29389090 |
Rabdosia rubescens (Hemsl.) - Reference Information
| properties | light yellow crystalline powder; Slightly gas, bitter. |
| Use | has anti-tumor, immunosuppression, anti-virus, anti-early pregnancy, change the skin epidermal keratinizing process. Clinically used for malignant tumor, psoriasis, cure warts, acute and chronic leukemia and schistosomiasis caused by hepatosplenomegaly. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: oridonin on a variety of cancer cells has a strong inhibitory effect, mainly used for anti-cancer, anti-bacterial, anti-tumor, insecticidal detoxification, anti-inflammatory pain, stomach and blood circulation and other effects. |
| rabdosia rubescens extract | oridonin, also known as oridonin, it is a kind of kauriene diterpenoid compound extracted from the leaves of rabdosia of Labiatae, which has the effects of clearing away heat and detoxification, reducing inflammation and pain, strengthening stomach and promoting blood circulation, and good anti-tumor activity, it has been found that it has inhibitory effect on lung cancer, prostate cancer, breast cancer and other cell lines. |
| biological activity | Oridonin (Isodonol, Rubescenin, NSC-250682) is an enantiomeric kaurane diterpene isolated from Rabdosia rubescens, is a kind of anti-tumor, anti-bacterial and anti-infection effect of traditional Chinese medicine. Oridonin inhibits the kinase activity of AKT1 and AKT2, corresponding to IC50 values of 8.4 μm and 8.9 μm, respectively. |
| Target | Value |
| Akt1 (Cell-free assay) | 8.4 μM |
| Akt2 (Cell-free assay) | 8.9 μM |
Last Update：2024-04-09 20:52:54
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Product Name: Rabdosia rubescens (Hemsl.) Visit Supplier Webpage Request for quotation
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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